Publications

My research integrates spatial histopathology, transcriptomics, and medical imaging using machine learning (ML) to study and diagnose post-traumatic joint conditions of contracture and osteoarthritis. I develop ML models end-to-end to identify tissue and cellular subtypes, phenotypes, and predictive relationships. My ML models are built upon preclinical and clinical datasets involving the ankle, elbow, and knee.

Topic areas: Machine Learning, Deep Learning, Post-Traumatic Osteoarthritis, Musculoskeletal Biology, Biomedical Engineering, Multi-omics, Medical Imaging, Spatial histopathology.

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Research areas (word cloud)

Word cloud of recurring terms across Michael A. David's publications — A snapshot of recurring themes across publications (auto-generated from PubMed MeSH/keywords when available).

animals cartilage and male mice osteoarthritis aged articular c57bl cells chondrocytes humans inbred injuries studies age ankle calcium joint meniscus chondrocyte elbow post-traumatic 2

Highlighted

Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways

Julia Matthias · Sara Buckley · M.A. David · Cheryl L. Ackert‐Bicknell · Joshua A. Metzl · et al.

Journal of Orthopaedic Research · 2025

Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture

M.A. David · Alex J. Reiter · Chelsey L. Dunham · Ryan M. Castile · James A. Abraham · et al.

Frontiers in Bioengineering and Biotechnology · 2022

Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse

M.A. David · Melanie K. Smith · Rachael N. Pilachowski · Avery T. White · Ryan C. Locke · et al.

Journal of Orthopaedic Research · 2016

Tendon Repair Is Compromised in a High Fat Diet-Induced Mouse Model of Obesity and Type 2 Diabetes

M.A. David · Khyrie H. Jones · Jason A. Inzana · Michael J. Zuscik · Hani A. Awad · et al.

PLoS ONE · 2014

All (10)

Tip: use the search box to filter by keywords, or try advanced tokens like year:2023 (or year:2020-2022) and type:journal.

2025

Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways

Julia Matthias , Sara Buckley , Michael David , Cheryl L. Ackert‐Bicknell , Joshua A. Metzl , et al.

Journal of Orthopaedic Research · 02 Jul 2025 · doi:10.1002/jor.70016

2022

Optical Imaging of Dynamic Collagen Processes in Health and Disease

Leanne E. Iannucci , Charles S. Dranoff , Michael A. David , Spencer P. Lake

Frontiers in Mechanical Engineering · 18 Mar 2022 · doi:10.3389/fmech.2022.855271

Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture

Michael A. David , Alex J. Reiter , Chelsey L. Dunham , Ryan M. Castile , James A. Abraham , et al.

Frontiers in Bioengineering and Biotechnology · 21 Feb 2022 · doi:10.3389/fbioe.2022.803403

2021

Preclinical models of elbow injury and pathology

Michael A. David , Aaron M. Chamberlain , Spencer P. Lake

Annals of Joint · 01 Jan 2021 · doi:10.21037/aoj.2020.02.09

2019

Local Intra-Articular Delivery of Zoledronic Acid as a Disease-Modifying Therapeutic for Post-Traumatic Osteoarthritis

Michael A. David

University of Delaware Dissertation · 01 Jan 2019 · [no id info]

2017

Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices

Tianzhi Luo , Michael A. David , Lucas C. Dunshee , Rebecca A. Scott , Morgan A. Urello , et al.

Biomacromolecules · 01 Aug 2017 · doi:10.1021/acs.biomac.7b00686

2016

Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse

Michael A. David , Melanie K. Smith , Rachael N. Pilachowski , Avery T. White , Ryan C. Locke , et al.

Journal of Orthopaedic Research · 06 Oct 2016 · doi:10.1002/jor.23443

Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing

Ian M. Berke , Joseph P. Miola , Michael A. David , Melanie K. Smith , Christopher Price

PLOS ONE · 01 Mar 2016 · doi:10.1371/journal.pone.0150268

2015

Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes

Yilu Zhou , Michael A. David , Xingyu Chen , Leo Q. Wan , Randall L. Duncan , et al.

Annals of Biomedical Engineering · 29 Jul 2015 · doi:10.1007/s10439-015-1406-4

2014

Tendon Repair Is Compromised in a High Fat Diet-Induced Mouse Model of Obesity and Type 2 Diabetes

Michael A. David , Khyrie H. Jones , Jason A. Inzana , Michael J. Zuscik , Hani A. Awad , et al.

PLoS ONE · 21 Mar 2014 · doi:10.1371/journal.pone.0091234