Research

My research integrates spatial histopathology, transcriptomics, and medical imaging using machine learning (ML) to study and diagnose post-traumatic joint conditions of contracture and osteoarthritis. I develop ML models end-to-end to identify tissue and cellular subtypes, phenotypes, and predictive relationships. My ML models are built upon preclinical and clinical datasets involving the ankle, elbow, and knee.

Topic areas: Machine Learning, Deep Learning, Post-Traumatic Osteoarthritis, Musculoskeletal Biology, Biomedical Engineering, Multi-omics, Medical Imaging, Spatial histopathology.

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2025

Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways

Julia Matthias, Sara Buckley, Michael David, Cheryl L. Ackert‐Bicknell, Joshua A. Metzl, Daniel K. Moon, Courtney Miller, Michael J. Zuscik, Kenneth J. Hunt

Journal of Orthopaedic Research  ·  02 Jul 2025  ·  doi:10.1002/jor.70016

2022

Optical Imaging of Dynamic Collagen Processes in Health and Disease

Leanne E. Iannucci, Charles S. Dranoff, Michael A. David, Spencer P. Lake

Frontiers in Mechanical Engineering  ·  18 Mar 2022  ·  doi:10.3389/fmech.2022.855271

Pleiotropic Effects of Simvastatin and Losartan in Preclinical Models of Post-Traumatic Elbow Contracture

Michael A. David, Alex J. Reiter, Chelsey L. Dunham, Ryan M. Castile, James A. Abraham, Leanne E. Iannucci, Ishani D. Shah, Necat Havlioglu, Aaron M. Chamberlain, Spencer P. Lake

Frontiers in Bioengineering and Biotechnology  ·  21 Feb 2022  ·  doi:10.3389/fbioe.2022.803403

2021

Preclinical models of elbow injury and pathology

Michael A. David, Aaron M. Chamberlain, Spencer P. Lake

Annals of Joint  ·  01 Jan 2021  ·  doi:10.21037/aoj.2020.02.09

2017

Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices

Tianzhi Luo, Michael A. David, Lucas C. Dunshee, Rebecca A. Scott, Morgan A. Urello, Christopher Price, Kristi L. Kiick

Biomacromolecules  ·  01 Aug 2017  ·  doi:10.1021/acs.biomac.7b00686

2016

Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse

Michael A. David, Melanie K. Smith, Rachael N. Pilachowski, Avery T. White, Ryan C. Locke, Christopher Price

Journal of Orthopaedic Research  ·  06 Oct 2016  ·  doi:10.1002/jor.23443

Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing

Ian M. Berke, Joseph P. Miola, Michael A. David, Melanie K. Smith, Christopher Price

PLOS ONE  ·  01 Mar 2016  ·  doi:10.1371/journal.pone.0150268

2015

Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes

Yilu Zhou, Michael A. David, Xingyu Chen, Leo Q. Wan, Randall L. Duncan, Liyun Wang, X. Lucas Lu

Annals of Biomedical Engineering  ·  29 Jul 2015  ·  doi:10.1007/s10439-015-1406-4

2014

Tendon Repair Is Compromised in a High Fat Diet-Induced Mouse Model of Obesity and Type 2 Diabetes

Michael A. David, Khyrie H. Jones, Jason A. Inzana, Michael J. Zuscik, Hani A. Awad, Robert A. Mooney

PLoS ONE  ·  21 Mar 2014  ·  doi:10.1371/journal.pone.0091234